Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581418 | 0.91 | KCNH2 (0.69) | KCNH2 | |
| Urea SCHEMBL4437676 | 0.79 | ROCK2 (0.54) | KCNH2 | |
| SCHEMBL8692637 | 0.79 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL4295429 | 0.79 | KCNH2 (0.60) | KCNH2 | |
| SCHEMBL8692718 | 0.74 | KCNH2 (0.72) | KCNH2 | |
| SCHEMBL6994296 | 0.73 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL8691777 | 0.71 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL11834266 | 0.71 | KCNH2 (0.74) | KCNH2 | |
| SCHEMBL6992728 | 0.70 | KCNH2 (0.57) | KCNH2 | |
| SCHEMBL2476989 | 0.70 | ABCB11 (0.46) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489341-B1 | REDUCING OR AVOIDING ADVERSE EFFECTS ASSOCIATED WITH THE ADMINISTRATION OF SERTINDOLE, BY ADMINISTRATING A SERTINDOLE DERIVATIVE SUCH AS NOR-SERTINDOLE, 5-OXO-SERTINDOLE, DEHYDRO-SERTINDOLE OR DEHYDRO-NOR-SERTINDOLE | SEPRACOR INC. | 2002-12-03 | — | — | US | disclosed |
| WO-2000072837-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLEPTIC AND RELATED DISORDERS USING SERTINDOLE DERIVATIVES | SEPRACOR INC. (US) | 2000-12-07 | — | — | WO | disclosed |