Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654556 | 0.81 | KMT2A (0.35) | KMT2AKDM4EALDH1A1MEN1CYP2C9 | |
| SCHEMBL7663607 | 0.81 | — | — | |
| SCHEMBL7651968 | 0.78 | KDM4E (0.40) | KMT2AKDM4EALDH1A1MEN1CYP2C9 | |
| SCHEMBL7654697 | 0.77 | MEN1 (0.31) | KMT2AMEN1CYP2C19 | |
| SCHEMBL7654547 | 0.76 | KMT2A (0.36) | KMT2AKDM4EALDH1A1MEN1CYP2C9 | |
| SCHEMBL7655707 | 0.76 | P4HTM (0.37) | KMT2AKDM4EALDH1A1MEN1CYP2C19 | |
| SCHEMBL7662074 | 0.73 | KMT2A (0.45) | KMT2AKDM4EALDH1A1MEN1CYP2C9 | |
| SCHEMBL7661229 | 0.71 | CYP1A2 (0.38) | KDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7659400 | 0.71 | AKR1C3 (0.39) | KMT2AKDM4EALDH1A1MEN1CYP2C9 | |
| SCHEMBL7662443 | 0.70 | KMT2A (0.36) | KMT2AKDM4EALDH1A1MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |