Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DDO | Q99489 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654547 | 0.80 | KMT2A (0.36) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7654556 | 0.79 | KMT2A (0.35) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7108649 | 0.79 | TSPO (0.30) | ALDH1A1KMT2AMEN1CYP2C9ROCK2 | |
| SCHEMBL7651976 | 0.78 | KMT2A (0.37) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7654546 | 0.76 | KMT2A (0.38) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7659400 | 0.75 | AKR1C3 (0.39) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7103531 | 0.74 | MEN1 (0.33) | KDM4EALDH1A1KMT2AMEN1ROCK2 | |
| SCHEMBL7655696 | 0.73 | P4HTM (0.40) | KDM4EALDH1A1KMT2AL3MBTL1ROCK2 | |
| SCHEMBL7662443 | 0.73 | KMT2A (0.36) | KDM4EALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL7662074 | 0.73 | KMT2A (0.45) | KDM4EALDH1A1KMT2AMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |