Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370615 | 0.83 | CFTR (0.56) | SIRT6TDP1ALDH1A1MAPK1MAPT | |
| SCHEMBL4856254 | 0.82 | NPSR1 (0.47) | TDP1NPSR1ALDH1A1HPGDVCAM1 | |
| SCHEMBL15456899 | 0.82 | CHEK1 (0.49) | SIRT6TDP1NPSR1ALDH1A1HPGD | |
| SCHEMBL4854941 | 0.82 | NPSR1 (0.47) | SIRT6TDP1NPSR1ALDH1A1HPGD | |
| SCHEMBL18562538 | 0.81 | NPSR1 (0.46) | NPSR1ALDH1A1HPGDCNR1CNR2 | |
| SCHEMBL6981667 | 0.79 | KMT2A (0.51) | TDP1NPSR1ALDH1A1HPGDPOLB | |
| SCHEMBL4857830 | 0.79 | ALDH1A1 (0.49) | TDP1NPSR1ALDH1A1HPGDCNR1 | |
| SCHEMBL732303 | 0.79 | THRB (0.49) | NPSR1ALDH1A1HPGDVCAM1CNR1 | |
| SCHEMBL20302045 | 0.79 | NPSR1 (0.47) | NPSR1ALDH1A1HPGDVCAM1CNR1 | |
| SCHEMBL27868621 | 0.78 | SIRT6 (0.46) | SIRT6TDP1NPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |