Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813336 | 0.82 | CHEK1 (0.48) | CHEK1BRD4MAOBLMNAALDH1A1 | |
| SCHEMBL27929414 | 0.79 | ALDH1A1 (0.38) | LMNAALDH1A1GAAMAPTKMT2A | |
| SCHEMBL2153528 | 0.77 | CA4 (0.48) | MAOBLMNAALDH1A1RAB9ACYP1A2 | |
| SCHEMBL3455245 | 0.77 | ABL1 (0.60) | BRD4ADORA2AADORA1MAOBLMNA | |
| SCHEMBL28813103 | 0.77 | ALDH1A1 (0.37) | LMNAALDH1A1GAAMEN1MAPT | |
| SCHEMBL2020140 | 0.77 | ABL1 (0.59) | BRD4ADORA2AADORA1MAOBLMNA | |
| SCHEMBL7308295 | 0.74 | CHEK1 (0.41) | CHEK1BRD4ADORA2AADORA1MAOB | |
| SCHEMBL25798209 | 0.74 | NFE2L2 (0.42) | LMNAALDH1A1GAARAB9AMEN1 | |
| SCHEMBL13211663 | 0.73 | ABL1 (0.60) | BRD4ADORA2AADORA1MAOBLMNA | |
| SCHEMBL13240564 | 0.72 | CA12 (0.46) | LMNAALDH1A1RAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926152-B1 | Process for the manufacture of bis(phosphine oxide)-and bis(phosphonate)-compounds | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |