Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212954 | 0.89 | PDE5A (0.43) | SLC10A2PDE5AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7652710 | 0.86 | SLC10A2 (0.40) | SLC10A2ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL16689302 | 0.81 | CFD (0.47) | PDE5AALDH1A1KDM4ESMN1; SMN2DHFR | |
| SCHEMBL6764928 | 0.79 | ALDH1A1 (0.40) | SLC10A2PDE5AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16689309 | 0.79 | CFD (0.45) | SLC10A2PDE5AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6950219 | 0.77 | PDGFRB (0.40) | PDE5AALDH1A1KDM4ESMN1; SMN2DHFR | |
| SCHEMBL4738100 | 0.74 | PDE3A (0.50) | ALDH1A1DHFR | |
| SCHEMBL6765497 | 0.74 | SLC10A2 (0.45) | SLC10A2ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL11209986 | 0.73 | SMN1; SMN2 (0.45) | SLC10A2ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL7653476 | 0.72 | SLC10A2 (0.40) | SLC10A2ALDH1A1GAASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |