Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7652032 | 0.99 | TLR9 (0.49) | TLR9TLR7EHMT2KDM4EMEN1 | |
| SCHEMBL6954049 | 0.87 | ADRA1A (0.60) | TLR9TLR7EHMT2KDM4EMEN1 | |
| SCHEMBL7006705 | 0.85 | KDM4E (0.51) | KDM4EHPGD | |
| SCHEMBL7649027 | 0.83 | ADRA1D (0.44) | EHMT2 | |
| SCHEMBL7011047 | 0.82 | KDM4E (0.47) | EHMT2KDM4EMEN1HPGDKMT2A | |
| SCHEMBL7654368 | 0.82 | EHMT2 (0.47) | TLR9TLR7EHMT2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7652736 | 0.79 | ADRA1A (0.57) | KDM4EMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL6765566 | 0.77 | AKR1C3 (0.45) | KDM4EHPGD | |
| SCHEMBL7013535 | 0.76 | KDM4E (0.46) | KDM4EMEN1HPGDKMT2A | |
| SCHEMBL6771678 | 0.75 | AKR1C3 (0.40) | KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |