Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647520 | 0.84 | HDAC1 (0.35) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL8661431 | 0.79 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL1307547 | 0.79 | HDAC3 (0.67) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7647791 | 0.79 | CYP2C19 (0.42) | GAAKDM4ECYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL8459366 | 0.77 | MGAM (0.50) | MAPTMEN1KMT2APKMGPR84 | |
| SCHEMBL23292956 | 0.75 | MGAM (0.64) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL10759703 | 0.75 | HTR2A (0.59) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL1306354 | 0.73 | HDAC3 (0.67) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7647686 | 0.73 | CCKBR (0.39) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL10990218 | 0.73 | GPR84 (0.59) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |