Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | SI | P14410 | 7/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459378 | 0.84 | HPGDS (0.41) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL1893849 | 0.79 | MEN1 (0.59) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL7654118 | 0.77 | HDAC3 (0.48) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL1350711 | 0.75 | MGAM (0.58) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL11372142 | 0.74 | GPR84 (0.60) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL7047429 | 0.73 | MEN1 (0.59) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL3370820 | 0.73 | MEN1 (0.59) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL9730408 | 0.73 | GPR84 (0.54) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL29263805 | 0.73 | MEN1 (0.52) | MGAMGAASIMGAM2NOD2 | |
| SCHEMBL29263804 | 0.73 | MEN1 (0.52) | MGAMGAASIMGAM2NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |