Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7650150 | 0.78 | BCHE (0.44) | MAPTLMNACNR2ALDH1A1KDM4E | |
| SCHEMBL7654430 | 0.74 | TNF (0.70) | CNR2ALDH1A1KDM4ETNFHTT | |
| SCHEMBL7649768 | 0.74 | TNF (0.70) | CNR2ALDH1A1KDM4ETNFHTT | |
| SCHEMBL7654436 | 0.72 | HDAC8 (0.47) | MAPTCNR2TNF | |
| SCHEMBL7655652 | 0.71 | CYP1A2 (0.54) | MAPTLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7649846 | 0.71 | TNF (0.59) | LMNACNR2ALDH1A1KDM4ETNF | |
| SCHEMBL10760314 | 0.70 | TSHR (0.56) | LMNACNR2KDM4ETNFHTT | |
| SCHEMBL5036947 | 0.69 | TNF (0.62) | LMNACNR2ALDH1A1KDM4ETNF | |
| SCHEMBL7655134 | 0.69 | TNF (0.51) | LMNACNR2ALDH1A1KDM4ETNF | |
| SCHEMBL6417860 | 0.69 | CNR2 (0.68) | MAPTLMNACNR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |