Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649768 | 0.74 | TNF (0.70) | HDAC1CNR2TNF | |
| SCHEMBL7654430 | 0.74 | TNF (0.70) | HDAC1CNR2TNF | |
| SCHEMBL5036947 | 0.73 | TNF (0.62) | HDAC1CNR2TNF | |
| SCHEMBL7651124 | 0.73 | PGR (0.68) | MAPT | |
| SCHEMBL7654823 | 0.72 | MAPT (0.52) | CNR2MAPTTNF | |
| SCHEMBL8831732 | 0.72 | RORA (0.69) | HDAC8HDAC6HDAC1HDAC11 | |
| SCHEMBL9559954 | 0.71 | FOLH1 (0.58) | FOLH1 | |
| SCHEMBL7649846 | 0.71 | TNF (0.59) | CNR2TNF | |
| SCHEMBL8791639 | 0.71 | FOLH1 (0.61) | FOLH1 | |
| SCHEMBL6417860 | 0.70 | CNR2 (0.68) | CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |