Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NAMPT | P43490 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656460 | 0.82 | POLB (0.60) | KMT2AMEN1LMNARAB9APOLB | |
| SCHEMBL166484 | 0.80 | LMNA (0.82) | KMT2AMEN1LMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27843329 | 0.79 | LMNA (0.80) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL1393086 | 0.78 | LMNA (1.00) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL19473341 | 0.77 | NPC1 (0.68) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL21768049 | 0.76 | LMNA (0.76) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL6629782 | 0.76 | MAPK14 (0.70) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL4893253 | 0.76 | NPC1 (0.71) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL17131896 | 0.75 | ALDH1A1 (1.00) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL18031536 | 0.75 | LMNA (0.74) | KMT2AMEN1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |