Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654965 | 0.82 | KMT2A (0.65) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17744942 | 0.82 | HDAC6 (0.68) | POLBHDAC6HDAC2HDAC8MAPT | |
| SCHEMBL673385 | 0.81 | HDAC1 (0.69) | POLBCYP3A4CYP2C9HDAC6HDAC2 | |
| SCHEMBL11900090 | 0.80 | HDAC6 (0.85) | POLBHDAC6HDAC2HDAC8HPGD | |
| SCHEMBL7657652 | 0.79 | POLB (0.76) | POLBCYP3A4CYP2C9HDAC6HDAC2 | |
| SCHEMBL18601428 | 0.78 | KMT2A (0.68) | POLBHDAC6HDAC2HDAC8MEN1 | |
| SCHEMBL1383257 | 0.77 | POLB (1.00) | POLBCYP3A4CYP2C9HDAC6HDAC2 | |
| SCHEMBL457082 | 0.77 | HDAC6 (0.79) | HDAC6HDAC2HDAC8ALDH1A1HPGD | |
| SCHEMBL7651627 | 0.76 | POLB (0.76) | POLBCYP3A4CYP2C9BLMMEN1 | |
| SCHEMBL28616232 | 0.76 | HDAC6 (0.59) | POLBHDAC6HDAC2HDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |