Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665570 | 0.92 | MAPT (0.39) | SIGMAR1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL7656125 | 0.89 | EP300 (0.56) | EP300SIGMAR1RAB9AHPGDMEN1 | |
| SCHEMBL7658829 | 0.87 | EP300 (0.53) | EP300RAB9AMEN1KMT2AF2 | |
| SCHEMBL7657863 | 0.83 | MAPT (0.36) | SIGMAR1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL7651041 | 0.82 | EP300 (0.45) | EP300HPGDMEN1KMT2AF2 | |
| SCHEMBL7661488 | 0.82 | EP300 (0.46) | EP300SIGMAR1RAB9AHPGDMEN1 | |
| SCHEMBL7658228 | 0.80 | EP300 (0.50) | EP300MEN1KMT2AGAAF2 | |
| SCHEMBL7841934 | 0.79 | ALDH1A1 (0.38) | SIGMAR1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL7657008 | 0.74 | EP300 (0.68) | EP300RAB9AHPGDMEN1KMT2A | |
| SCHEMBL7660452 | 0.74 | CCKBR (0.39) | EP300POLBALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498164-B1 | SUCH AS 1,3-DIBENZYL-5-(PHENYL- OR 2-THIENYL-ACETYL)BARBI-TURIC ACID; MALIGNANT HYPERCALCEMIA, OSTEOLYTIC DISEASES SUCH AS PAGET'S DISEASE, OSTEOPOROSIS, ARTICULAR RHEUMATISM OCCURRING IN KNEES, SHOULDERS, JOINTS | AVENTIS PHARMA S.A. (FR) | 2002-12-24 | — | — | US | claimed |
| US-6498164-B1 | SUCH AS 1,3-DIBENZYL-5-(PHENYL- OR 2-THIENYL-ACETYL)BARBI-TURIC ACID; MALIGNANT HYPERCALCEMIA, OSTEOLYTIC DISEASES SUCH AS PAGET'S DISEASE, OSTEOPOROSIS, ARTICULAR RHEUMATISM OCCURRING IN KNEES, SHOULDERS, JOINTS | AVENTIS PHARMA S.A. (FR) | 2002-12-24 | — | — | US | disclosed |
| EP-1064269-A1 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | Hoechst Marion Roussel (FR) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999050252-A2 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | HOECHST MARION ROUSSEL (FR) | 1999-10-07 | — | — | WO | disclosed |