Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665570 | 0.86 | MAPT (0.39) | ALDH1A1PKMHSD17B10MEN1KMT2A | |
| SCHEMBL7839682 | 0.81 | LMNA (0.36) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL7655852 | 0.79 | EP300 (0.46) | ALDH1A1MEN1KMT2AMAPTSIGMAR1 | |
| SCHEMBL7657863 | 0.78 | MAPT (0.36) | ALDH1A1PKMHSD17B10MEN1KMT2A | |
| SCHEMBL9835223 | 0.69 | MAPT (0.47) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL7656125 | 0.67 | EP300 (0.56) | ALDH1A1PKMMEN1KMT2ASIGMAR1 | |
| SCHEMBL10515431 | 0.65 | CASP3 (0.40) | ALDH1A1PKMHSD17B10MEN1KMT2A | |
| SCHEMBL9837308 | 0.64 | NPC1 (0.43) | HSD17B10MEN1KMT2APOLBNPC1 | |
| SCHEMBL7658829 | 0.63 | EP300 (0.53) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL681510 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064269-A1 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | Hoechst Marion Roussel (FR) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999050252-A2 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | HOECHST MARION ROUSSEL (FR) | 1999-10-07 | — | — | WO | disclosed |