Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CFD | P00746 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765694 | 0.87 | ADRA1A (0.50) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL6946914 | 0.87 | CFD (0.50) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL6765436 | 0.83 | ADRA1A (0.47) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL7653518 | 0.83 | CFD (0.50) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL6766548 | 0.82 | CFD (0.54) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL7010612 | 0.82 | ADRA1A (0.46) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL7014090 | 0.81 | ADRA1A (0.45) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL7014811 | 0.80 | ADRA1A (0.44) | ADRA1AADRA1BADRA2AADRA2BADRA2C | |
| SCHEMBL6762612 | 0.79 | CFD (0.49) | ADRA1AADRA1BCFD | |
| SCHEMBL7009182 | 0.79 | ADRA2B (0.62) | ADRA1AADRA1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |