Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656123 | 1.00 | MTNR1A (0.45) | MTNR1AMTNR1BPPARGPPARALMNA | |
| SCHEMBL16468198 | 0.90 | ALDH1A1 (0.43) | PPARGPPARA | |
| SCHEMBL17491904 | 0.87 | MTNR1A (0.46) | MTNR1AMTNR1BLMNACYP2D6MAOA | |
| SCHEMBL6221169 | 0.87 | MTNR1A (0.46) | MTNR1AMTNR1BLMNACYP2D6MAOA | |
| SCHEMBL17491905 | 0.87 | MTNR1A (0.46) | MTNR1AMTNR1BLMNACYP2D6MAOA | |
| SCHEMBL16094419 | 0.87 | HTT (0.47) | LMNAADRB2ADRB1 | |
| SCHEMBL16094416 | 0.87 | HTT (0.47) | LMNAADRB2ADRB1 | |
| SCHEMBL30854486 | 0.87 | RXRA (0.43) | CYP2D6 | |
| SCHEMBL28625906 | 0.87 | RXRA (0.43) | CYP2D6 | |
| SCHEMBL28597447 | 0.85 | SCN9A (0.47) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016160677-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2016-10-06 | — | — | WO | disclosed |
| US-6358978-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS (IN THE CASE OF INFLAMMATION), OSTEOARTHRITIS, ASTHMA, CARDIAC INFARCT, ALZHEIMER'S DISEASE, OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-19 | — | — | US | disclosed |