Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 5/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658556 | 0.89 | CTSL (0.42) | ITGAVCTSLCTSSCTSBCTSK | |
| SCHEMBL6737505 | 0.89 | CTSL (0.42) | ITGAVCTSLCTSSCTSBCTSK | |
| SCHEMBL6062021 | 0.88 | PPARG (0.46) | ITGAVCTSLCTSSCTSBCTSK | |
| SCHEMBL6740637 | 0.87 | CTSL (0.46) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6737451 | 0.86 | ALDH1A1 (0.50) | ITGAVHPGDCTSLCTSSCTSB | |
| SCHEMBL6740031 | 0.85 | CTSL (0.46) | ITGAVCTSLCTSSCTSBCTSK | |
| SCHEMBL6741598 | 0.85 | CTSL (0.46) | ITGAVCTSLCTSSCTSBCTSK | |
| SCHEMBL6740731 | 0.85 | CTSL (0.46) | CTSLCTSSCTSBCTSKKMT2A | |
| SCHEMBL6744804 | 0.85 | CTSL (0.46) | ITGAVCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL7661877 | 0.84 | CTSL (0.43) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492362-B1 | Compounds and compositions as cathepsin S inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |