Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 7/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368712 | 0.90 | CAMK2D (0.33) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL7659483 | 0.90 | CAMK2D (0.39) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8366859 | 0.90 | CAMK2D (0.33) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8368564 | 0.88 | CAMK2D (0.36) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL7664679 | 0.88 | CAMK2D (0.32) | CAMK2D | |
| SCHEMBL8516682 | 0.85 | GSK3B (0.38) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8365231 | 0.85 | CNR2 (0.37) | CAMK2DPCSK9 | |
| SCHEMBL7662107 | 0.85 | CAMK2D (0.45) | CAMK2DGSK3BUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8516363 | 0.85 | MAPT (0.36) | ALDH1A1 | |
| SCHEMBL7656438 | 0.79 | CAMK2D (0.42) | CAMK2DGSK3BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |