Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656477 | 1.00 | HSD11B1 (0.47) | HSD11B1TNFRSF1AGRIK1GRIK2PTGS1 | |
| SCHEMBL7651688 | 0.83 | CYP1A2 (0.47) | GRIK1GRIK2MAOBLMNACYP1A2 | |
| SCHEMBL7650815 | 0.83 | RAB9A (0.46) | GRIK1GRIK2POLBMAOBLMNA | |
| SCHEMBL7651686 | 0.83 | CYP1A2 (0.47) | GRIK1GRIK2MAOBLMNACYP1A2 | |
| SCHEMBL7650821 | 0.83 | RAB9A (0.46) | GRIK1GRIK2POLBMAOBLMNA | |
| SCHEMBL7657357 | 0.82 | PAM (0.53) | MAOBLMNACYP1A2MAPTCYP2C9 | |
| SCHEMBL2043779 | 0.82 | HSD11B1 (0.50) | HSD11B1TNFRSF1AGRIK1GRIK2PTGS1 | |
| SCHEMBL727448 | 0.82 | HSD11B1 (0.50) | HSD11B1TNFRSF1AGRIK1GRIK2PTGS1 | |
| SCHEMBL727447 | 0.82 | HSD11B1 (0.50) | HSD11B1TNFRSF1AGRIK1GRIK2PTGS1 | |
| SCHEMBL7657362 | 0.82 | PAM (0.53) | MAOBLMNACYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6491903-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY | WASHINGTON UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-6383500-B1 | Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications | WASHINGTON UNIVERSITY | 2002-05-07 | — | — | US | disclosed |