Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 9/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392163 | 0.87 | LMNA (0.39) | SCN4ATSHRLMNASCN1ASCN5A | |
| SCHEMBL764855 | 0.82 | LMNA (0.39) | SCN4ATSHRLMNASCN1ASCN5A | |
| SCHEMBL14260234 | 0.81 | LMNA (0.34) | LMNACYP2D6KMT2A | |
| SCHEMBL28634561 | 0.80 | LMNA (0.52) | SCN4ATSHRLMNASCN1ASCN5A | |
| SCHEMBL765338 | 0.79 | LMNA (0.39) | SCN4ATSHRLMNASLC6A4KCNH2 | |
| SCHEMBL750165 | 0.77 | ALOX15 (0.48) | TSHRLMNASLC6A4KCNH2CYP1A2 | |
| SCHEMBL13392154 | 0.76 | LMNA (0.39) | LMNACYP3A4MEN1KMT2A | |
| SCHEMBL31575355 | 0.71 | SLC6A2 (0.48) | LMNASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL14260232 | 0.70 | LMNA (0.34) | LMNASLC6A4CYP3A4CYP2C9SCN8A | |
| SCHEMBL768372 | 0.68 | TSHR (0.53) | SCN4ATSHRKCNH2GBA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |