Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392162 | 0.87 | LMNA (0.40) | LMNANR2E1ALOX15CYP2C19KMT2A | |
| SCHEMBL10150236 | 0.83 | LMNA (0.39) | LMNANR2E1ALOX15CYP2C19KMT2A | |
| SCHEMBL10150183 | 0.80 | ALDH1A1 (0.36) | LMNANR2E1ALOX15KMT2AKDM4E | |
| SCHEMBL765684 | 0.79 | SCN4A (0.44) | LMNASCN4ANR2E1ALOX15KMT2A | |
| SCHEMBL750165 | 0.78 | ALOX15 (0.48) | LMNANR2E1ALOX15KDM4EALDH1A1 | |
| SCHEMBL13392155 | 0.77 | LMNA (0.39) | LMNAKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL13894250 | 0.76 | LMNA (0.55) | LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL768503 | 0.72 | ALOX15 (0.59) | LMNANR2E1ALOX15KMT2AKDM4E | |
| SCHEMBL768502 | 0.72 | ALOX15 (0.59) | LMNANR2E1ALOX15KMT2AKDM4E | |
| SCHEMBL14260258 | 0.71 | KDM4E (0.38) | LMNAKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |