Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PLAT | P00750 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 5/20 | 0.40 |
| ▸ | F7 | P08709 | 4/20 | 0.40 |
| ▸ | F3 | P13726 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149446 | 0.84 | NPC1 (0.59) | NPC1RAB9AFFAR1HNF4AMYC | |
| SCHEMBL7663102 | 0.81 | FFAR1 (0.43) | NPC1RAB9AASIC3FFAR1PLAU | |
| SCHEMBL7655674 | 0.79 | F7 (0.69) | F10F2F7F3PRSS1 | |
| SCHEMBL27670241 | 0.76 | WDR5 (0.58) | PLAUPLATF10F2F7 | |
| SCHEMBL5667272 | 0.76 | NPC1 (0.46) | NPC1RAB9AFFAR1SLC16A3HNF4A | |
| SCHEMBL18574217 | 0.75 | ASIC3 (0.71) | ASIC3PLAUF10F2F7 | |
| SCHEMBL27503029 | 0.75 | FFAR1 (0.46) | NPC1RAB9AFFAR1SLC16A3HNF4A | |
| SCHEMBL69187 | 0.75 | NPC1 (0.59) | NPC1RAB9AFFAR1SLC16A3HNF4A | |
| SCHEMBL30607509 | 0.74 | NPC1 (0.67) | NPC1RAB9AFFAR1SLC16A3HNF4A | |
| SCHEMBL29188167 | 0.74 | MYC (0.53) | HNF4AMYCKMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | claimed |
| EP-1078917-A1 | AMIDINO DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-28 | — | — | EP | claimed |