Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650334 | 0.86 | ALDH1A1 (0.55) | KMT2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL6301593 | 0.86 | HDAC1 (0.54) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL6301558 | 0.84 | KMT2A (0.48) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL6301341 | 0.84 | KMT2A (0.48) | KMT2ASMN1; SMN2PKMLMNAMAPT | |
| SCHEMBL6301182 | 0.83 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL6301145 | 0.82 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL6430006 | 0.82 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL6303883 | 0.82 | RAB9A (0.59) | KMT2ASMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL6301413 | 0.81 | KMT2A (0.45) | KMT2ASMN1; SMN2MEN1PKMLMNA | |
| SCHEMBL6298861 | 0.78 | KMT2A (0.55) | KMT2ASMN1; SMN2MEN1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1020452-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |