Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 5/20 | 0.48 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656495 | 0.87 | F10 (0.57) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7664168 | 0.83 | F10 (0.52) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7661381 | 0.82 | LMNA (0.65) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7664158 | 0.80 | LMNA (0.58) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL679294 | 0.74 | PLAU (0.51) | F10PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL13925788 | 0.74 | PLAU (0.51) | F10PRSS1PRSS2PRSS3F2 | |
| Hydrochloric Acid SCHEMBL7654805 | 0.74 | PLAU (0.61) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL9303020 | 0.73 | NR1H4 (0.53) | F10PRSS1F2PLAUPLAT | |
| SCHEMBL4901667 | 0.73 | SLC7A5 (0.52) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL27453091 | 0.73 | ALDH1A1 (0.56) | F2TMPRSS6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| EP-1078917-A1 | AMIDINO DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-28 | — | — | EP | disclosed |