Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661252 | 0.89 | ADORA1 (0.47) | MEN1KMT2AADORA1ADORA2BADORA3 | |
| SCHEMBL7656833 | 0.88 | KMT2A (0.50) | TSHRMEN1KMT2AADORA1ADORA2B | |
| SCHEMBL8560002 | 0.83 | ADORA1 (0.58) | MEN1KMT2AADORA1ADORA2BADORA3 | |
| SCHEMBL7001583 | 0.81 | ADORA2A (0.49) | MEN1KMT2AADORA2BADORA3ALDH1A1 | |
| SCHEMBL7670431 | 0.70 | ADORA2B (0.54) | TSHRMAPK1MEN1KMT2AADORA1 | |
| SCHEMBL8560750 | 0.69 | PDE4A (0.52) | ADORA1ADORA2BADORA3HSD17B10ADORA2A | |
| SCHEMBL7659412 | 0.67 | ADORA2B (0.45) | TSHRMAPK1MEN1KMT2AADORA1 | |
| SCHEMBL7666682 | 0.67 | ADORA3 (0.50) | TSHRMEN1KMT2AADORA1ADORA2B | |
| SCHEMBL836300 | 0.66 | ADORA2B (0.55) | TSHRMAPK1MEN1KMT2AADORA1 | |
| SCHEMBL7668670 | 0.66 | ADORA2B (0.51) | TSHRMAPK1MEN1KMT2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |