Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563751 | 0.83 | ADORA3 (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8560745 | 0.83 | ADORA2A (0.44) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8560002 | 0.77 | ADORA1 (0.58) | ADORA2AADORA2BADORA3ADORA1HSD17B10 | |
| SCHEMBL4202952 | 0.77 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7666660 | 0.77 | ADORA2B (0.54) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7001583 | 0.76 | ADORA2A (0.49) | ADORA2AADORA2BADORA3HSD17B10 | |
| SCHEMBL7665201 | 0.74 | ADORA2A (0.45) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8559651 | 0.72 | ADORA2B (0.61) | ADORA2AADORA2BADORA3HPGDADORA1 | |
| SCHEMBL8562832 | 0.71 | ADORA2B (0.43) | ADORA2AADORA2BADORA3HPGDADORA1 | |
| SCHEMBL7738361 | 0.70 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |