Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | KAT2A | Q92830 | 4/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764358 | 0.82 | FAAH (0.66) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL15423262 | 0.82 | FAAH (0.69) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL30434016 | 0.81 | FAAH (0.72) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL28455721 | 0.81 | FAAH (0.72) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL24836231 | 0.79 | FAAH (0.81) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL24836228 | 0.77 | FAAH (0.84) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL7019817 | 0.76 | FAAH (0.54) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL7019813 | 0.76 | FAAH (0.54) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL24836229 | 0.76 | FAAH (0.76) | FAAHMGLLKAT2AKAT2BCASP3 | |
| SCHEMBL28206232 | 0.76 | KAT2A (0.58) | FAAHMGLLKAT2AKAT2BCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987321-B2 | Lisofylline analogs and methods for use | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140018355-A1 | LISOFYLLINE ANALOGS AND METHODS FOR USE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2014-01-16 | — | — | US | disclosed |
| US-8481580-B2 | interleukin 1, 12, tumor necrosis factor alpha, and trigger interferon- gamma antagonist; antiinflammatory , antidiabetic agent, autoimmune disorders; active side chain moiety (5-R-hydroxyhexyl) of lisofyllin, greater potency and oral bioavailability than lisofylline | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2325169-A9 | LISOFYLLINE ANALOGUES AND THEIR PHARMEACUETICAL USES | University Of Virginia Patent Foundation (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2325169-A2 | Lisofylline analogues and their pharmeacuetical uses | University Of Virginia Patent Foundation (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2007027719-A2 | LISOFYLLINE ANALOGUES AND THEIR PHARMEACUETICAL USES | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018355-A1 | LISOFYLLINE ANALOGS AND METHODS FOR USE | LPXN, LCT, SI | FAAH 323/4885MGLL 421/4885KAT2A 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.