Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657396 | 0.91 | PTPN2 (0.41) | PTPN2PTPN1PTPN5PGAM1AR | |
| SCHEMBL7665046 | 0.90 | HIF1A (0.42) | HIF1APTPN2PTPN1PTPN5PGAM1 | |
| SCHEMBL7858188 | 0.89 | TDP1 (0.45) | PTPN1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7659448 | 0.88 | TP53 (0.37) | HIF1APTPN2PTPN1PTPN5MAPT | |
| SCHEMBL7654281 | 0.87 | HIF1A (0.45) | HIF1APTPN2PTPN1PTPN5PGAM1 | |
| SCHEMBL7656711 | 0.85 | HIF1A (0.44) | HIF1APTPN2PTPN1PTPN5PGAM1 | |
| SCHEMBL7660123 | 0.84 | HSPD1 (0.47) | HIF1APTPN2PTPN1PTPN5MAPT | |
| SCHEMBL7657829 | 0.83 | MEN1 (0.38) | HIF1APTPN2PTPN1PTPN5MAPT | |
| SCHEMBL7855840 | 0.82 | PNMT (0.42) | MAPTMEN1KMT2ATP53THRB | |
| SCHEMBL7659818 | 0.82 | PKM (0.36) | HIF1APTPN2PTPN1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |