Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 12/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7658458 | 0.80 | CAMK2D (0.42) | CAMK2DKDRGSK3BPIM1CA12 | |
| Trifluoroacetic Acid SCHEMBL7654562 | 0.76 | CAMK2D (0.45) | CAMK2DPIM1 | |
| Acetic Acid SCHEMBL7658116 | 0.75 | CAMK2D (0.49) | CAMK2DKDRGSK3BPIM1CA12 | |
| SCHEMBL7664768 | 0.74 | CAMK2D (0.46) | CAMK2DKDRGSK3BCNR2PIM1 | |
| Trifluoroacetic Acid SCHEMBL7818314 | 0.73 | CAMK2D (0.48) | CAMK2DPIM1RPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7815291 | 0.72 | CAMK2D (0.46) | CAMK2DCNR2PIM1RPS6KB1 | |
| SCHEMBL7658866 | 0.71 | CAMK2D (0.38) | CAMK2DKDRGSK3BPIM1 | |
| SCHEMBL7659626 | 0.71 | CAMK2D (0.43) | CAMK2DKDRGSK3BPIM1 | |
| SCHEMBL7658933 | 0.70 | PDE4B (0.46) | CAMK2DKDRGSK3BCNR2 | |
| Acetic Acid SCHEMBL7665440 | 0.70 | CAMK2D (0.51) | CAMK2DKDRGSK3BPIM1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | claimed |
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |