Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 11/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7654562 | 0.87 | CAMK2D (0.45) | CAMK2DPIM1ALDH1A1USP2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL7807656 | 0.84 | MAPT (0.43) | CAMK2DPIM1KDM4EALDH1A1MAPT | |
| Acetic Acid SCHEMBL7658116 | 0.83 | CAMK2D (0.49) | CAMK2DKDRGSK3BPIM1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7817667 | 0.83 | CAMK2D (0.44) | CAMK2DPIM1KDM4E | |
| Trifluoroacetic Acid SCHEMBL7817211 | 0.82 | MAPT (0.43) | CAMK2DPIM1ALDH1A1MAPTUSP2 | |
| Trifluoroacetic Acid SCHEMBL7815291 | 0.82 | CAMK2D (0.46) | CAMK2DPIM1ALDH1A1MAPTMAPK1 | |
| SCHEMBL7658467 | 0.80 | CAMK2D (0.41) | CAMK2DKDRGSK3BPIM1CA12 | |
| Trifluoroacetic Acid SCHEMBL7818314 | 0.80 | CAMK2D (0.48) | CAMK2DPIM1KDM4EALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL7815071 | 0.80 | ALDH1A1 (0.49) | CAMK2DPIM1KDM4EALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL8516825 | 0.79 | CA12 (0.40) | CAMK2DPIM1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | claimed |
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |