Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655229 | 0.90 | ITGB3 (0.46) | ITGB3ITGAVITGA2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL7658105 | 0.87 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPK1HTTKMT2A | |
| SCHEMBL381839 | 0.87 | ITGB3 (0.54) | ITGB3ITGAVITGA2BCTSAP2RY12 | |
| SCHEMBL7654428 | 0.86 | ITGB3 (0.48) | ITGB3ITGAVITGA2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6496651 | 0.85 | KAT6A (0.47) | SMN1; SMN2ALDH1A1LMNAMAPK1P2RY12 | |
| SCHEMBL7657530 | 0.84 | ITGB3 (0.55) | ITGB3ITGAVITGA2BCTSAALDH1A1 | |
| SCHEMBL7652012 | 0.84 | SMN1; SMN2 (0.41) | ITGB3ITGA2BSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7658557 | 0.82 | ITGB3 (0.65) | ITGB3ITGAVITGA2B | |
| SCHEMBL382329 | 0.79 | ITGB3 (0.75) | ITGB3ITGAVITGA2BCTSA | |
| SCHEMBL7651960 | 0.79 | ITGB3 (0.43) | ITGB3ITGAVITGA2BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |