Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658571 | 0.87 | ITGB3 (0.45) | ALDH1A1MAPK1GAASMN1; SMN2HTT | |
| SCHEMBL7655229 | 0.86 | ITGB3 (0.46) | ALDH1A1MAPK1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL7653716 | 0.84 | SIRT6 (0.39) | ALDH1A1MAPTGAASMN1; SMN2HTT | |
| SCHEMBL7658088 | 0.84 | ITGB3 (0.59) | ALDH1A1MAPK1MAPTGAASMN1; SMN2 | |
| SCHEMBL7654428 | 0.82 | ITGB3 (0.48) | ALDH1A1MAPK1MAPTGAASMN1; SMN2 | |
| SCHEMBL6496651 | 0.82 | KAT6A (0.47) | ALDH1A1MAPK1MAPTSMN1; SMN2HTT | |
| SCHEMBL7658092 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPK1MAPTGAASMN1; SMN2 | |
| SCHEMBL12341345 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPK1MAPTGAASMN1; SMN2 | |
| SCHEMBL7652012 | 0.75 | SMN1; SMN2 (0.41) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7651960 | 0.75 | ITGB3 (0.43) | ALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |