Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651960 | 0.89 | ITGB3 (0.43) | SMN1; SMN2LMNAPTGDRALDH1A1MAPK1 | |
| SCHEMBL7653716 | 0.86 | SIRT6 (0.39) | SMN1; SMN2LMNAMEN1KMT2APTGDR | |
| SCHEMBL7654428 | 0.86 | ITGB3 (0.48) | SMN1; SMN2LMNAALDH1A1MAPK1ITGB3 | |
| SCHEMBL6496651 | 0.85 | KAT6A (0.47) | SMN1; SMN2LMNAKMT2AKDRALDH1A1 | |
| SCHEMBL7649780 | 0.84 | ITGB3 (0.44) | SMN1; SMN2FLT1FLT4KDRITGB3 | |
| SCHEMBL7658571 | 0.84 | ITGB3 (0.45) | SMN1; SMN2LMNAKMT2AALDH1A1MAPK1 | |
| SCHEMBL7651973 | 0.83 | ITGB3 (0.54) | SMN1; SMN2LMNAUSP2ITGB3ITGA2B | |
| SCHEMBL7653020 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2LMNAALDH1A1MAPK1ITGB3 | |
| SCHEMBL7655229 | 0.78 | ITGB3 (0.46) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7654380 | 0.77 | DRD2 (0.44) | SMN1; SMN2LMNAMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |