Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 20/20 | 0.59 |
| ▸ | DRD3 | P35462 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abt-925 SCHEMBL1078006 | 0.97 | DRD2 (0.62) | DRD2DRD3 | |
| Abt-925 SCHEMBL1078007 | 0.97 | DRD2 (0.62) | DRD2DRD3 | |
| Abt-925 SCHEMBL1043144 | 0.91 | DRD2 (0.67) | DRD2DRD3 | |
| Abt-925 SCHEMBL29462266 | 0.91 | DRD2 (0.67) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL4392115 | 0.85 | DRD2 (0.49) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL4392108 | 0.85 | DRD2 (0.49) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL4397762 | 0.85 | DRD2 (0.52) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL4397753 | 0.85 | DRD2 (0.52) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL1044942 | 0.84 | DRD2 (0.46) | DRD2DRD3 | |
| Fumaric Acid SCHEMBL27571134 | 0.84 | DRD2 (0.46) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352981-B1 | TREAT DISORDERS WHICH RESPOND TO DOPAMINE D.SUB.3 LIGANDS SUCH AS SCHISTOSOMIASIS, SCHIZOPHRENIA, DEPRESSION, NEUROSES OR PSYCHOSES | BASF AKTIENGESELLSCHAFT (DE) | 2002-03-05 | — | — | US | disclosed |