Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 4/20 | 0.49 |
| ▸ | FNTB | P49356 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653727 | 0.88 | FNTA (0.54) | FNTAFNTBCYP19A1ALDH1A1 | |
| SCHEMBL7657870 | 0.87 | FNTA (0.53) | FNTAFNTBCYP19A1PGGT1BALDH1A1 | |
| SCHEMBL7658747 | 0.85 | FNTA (0.46) | FNTAFNTBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7662195 | 0.83 | NAMPT (0.36) | FNTAFNTBCYP19A1CYP51A1NAMPT | |
| SCHEMBL7653592 | 0.79 | FNTA (0.41) | FNTAFNTBCYP19A1CYP3A4CYP2D6 | |
| SCHEMBL8187004 | 0.77 | FNTA (0.53) | FNTAFNTBCYP19A1ALDH1A1 | |
| SCHEMBL7654320 | 0.74 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL7653717 | 0.74 | FNTA (0.51) | FNTAFNTBALDH1A1 | |
| SCHEMBL7612446 | 0.74 | FNTA (0.53) | FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7660388 | 0.74 | FNTA (0.56) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025089-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 2000-08-09 | — | — | EP | claimed |
| WO-1999020612-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-04-29 | — | — | WO | claimed |
| US-6410539-B1 | ANTICARCINOGENIC AGENTS | ASTRAZENCA UK LIMITED (GB) | 2002-06-25 | — | — | US | disclosed |