Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658960 | 0.82 | GAA (0.41) | GAAMAPK14HTR1BPTGS2PDK1 | |
| SCHEMBL7656523 | 0.82 | PTGS2 (0.37) | GAACXCL8MAPK14PTGS2PDK1 | |
| SCHEMBL7655803 | 0.79 | MAPK14 (0.40) | GAAMAPK14PTGS2PDK1PDK2 | |
| SCHEMBL11429114 | 0.79 | LCK (0.51) | GAACXCL8MAPK14PDK1PDK2 | |
| SCHEMBL7656019 | 0.79 | GAA (0.41) | GAACXCL8MAPK14PTGS2PDK1 | |
| SCHEMBL7658940 | 0.79 | GAA (0.45) | GAAMAPK14PTGS2PDK1PDK2 | |
| SCHEMBL7656975 | 0.77 | GLA (0.44) | MAPK14 | |
| SCHEMBL11662825 | 0.76 | MAPK14 (0.51) | GAACXCL8MAPK14PTGS2PDK1 | |
| SCHEMBL16301207 | 0.76 | SMN1; SMN2 (0.51) | GAAMAPK14PTGS2 | |
| SCHEMBL5840516 | 0.75 | MAPT (0.44) | HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |