Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.42 |
| ▸ | ITGAV | P06756 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658972 | 1.00 | ITGB3 (0.42) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7145101 | 0.87 | ITGB3 (0.48) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7144223 | 0.86 | ROCK2 (0.42) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7144238 | 0.86 | ROCK2 (0.42) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7140579 | 0.84 | ITGB3 (0.42) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7138766 | 0.83 | LMNA (0.44) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7138784 | 0.81 | LMNA (0.42) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7146575 | 0.81 | ROCK2 (0.50) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7992257 | 0.80 | ROCK2 (0.46) | ITGB3ITGAVMAPTRAB9AALDH1A1 | |
| SCHEMBL7139124 | 0.80 | ALDH1A1 (0.43) | ITGB3ITGAVMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344562-B1 | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2002-02-05 | — | — | US | disclosed |