Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18253208 | 0.86 | MAPT (0.51) | MAPTHSD11B1GRIN2BLMNATYR | |
| SCHEMBL14403245 | 0.86 | DRD2 (0.39) | SLC6A4SLC6A3OPRM1OPRK1OPRL1 | |
| SCHEMBL9036581 | 0.83 | OPRL1 (0.46) | LMNASLC6A4SLC6A3OPRM1OPRK1 | |
| SCHEMBL613489 | 0.81 | OPRM1 (0.50) | SLC6A4SLC6A3OPRM1OPRK1OPRL1 | |
| SCHEMBL16437275 | 0.78 | HSD11B1 (0.50) | MAPTHSD11B1SMN1; SMN2GRIN2BLMNA | |
| SCHEMBL9343440 | 0.78 | HSD11B1 (0.50) | MAPTHSD11B1SMN1; SMN2GRIN2BLMNA | |
| SCHEMBL742824 | 0.77 | DRD2 (0.37) | SLC6A4SLC6A3OPRM1OPRK1OPRL1 | |
| SCHEMBL2385636 | 0.77 | OPRM1 (0.43) | SMN1; SMN2LMNASLC6A4SLC6A3OPRM1 | |
| SCHEMBL612754 | 0.77 | OPRM1 (0.43) | NPC1RAB9ASMN1; SMN2SLC6A4SLC6A3 | |
| SCHEMBL613410 | 0.77 | DRD2 (0.55) | MAPTSMN1; SMN2LMNASLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384065-B1 | CONTROL THE FUNCTIONS OF PROTEINS SUCH AS ENZYMES AND RECEPTOR FORTREATING INFLAMMATORY DISEASES SUCH AS RHEUMATOID ARTHRITIS, | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-1076056-A1 | NOVEL SPIRO COMPOUNDS OR SALTS THEREOF AND PREVENTIVES/REMEDIES FOR AUTOIMMUNE DISEASES AND AP-1 INHIBITORS CONTAINING THE SAME | TOYAMA CHEMICAL CO., LTD. (JP) | 2001-02-14 | — | — | EP | disclosed |