Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668891 | 0.81 | HTR2A (0.41) | TRPA1L3MBTL1SCN9ANPBWR1SLC6A4 | |
| SCHEMBL7666802 | 0.81 | TRPA1 (0.44) | TRPA1HSPB1NPBWR1MCHR1MAPK14 | |
| SCHEMBL7674060 | 0.75 | S1PR4 (0.50) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL10456772 | 0.74 | TRPA1 (0.56) | TRPA1MAP4K4HSPB1 | |
| SCHEMBL7668470 | 0.73 | KEAP1 (0.46) | L3MBTL1 | |
| SCHEMBL7666314 | 0.72 | L3MBTL1 (0.49) | MAP4K4L3MBTL1 | |
| SCHEMBL12825878 | 0.72 | TRPA1 (0.56) | TRPA1MAP4K4L3MBTL1HSPB1 | |
| SCHEMBL7665088 | 0.72 | NPSR1 (0.40) | MCHR1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL16650398 | 0.71 | TRPA1 (0.42) | TRPA1L3MBTL1HSPB1MAPK14 | |
| SCHEMBL7666779 | 0.71 | HTR2A (0.44) | L3MBTL1SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |