Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 7/20 | 0.50 |
| ▸ | TTR | P02766 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.49 |
| ▸ | CBR1 | P16152 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666779 | 0.80 | HTR2A (0.44) | HPGDMAPTSLC6A4ALDH1A1HTT | |
| SCHEMBL7663772 | 0.80 | S1PR4 (0.56) | S1PR4TTRSLC6A2SLC6A3HPGD | |
| SCHEMBL7186092 | 0.76 | TTR (0.75) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| SCHEMBL676629 | 0.75 | TTR (0.73) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| SCHEMBL7667376 | 0.75 | L3MBTL1 (0.39) | HPGDLMNAMAPTALDH1A1HTT | |
| SCHEMBL7659916 | 0.75 | TRPA1 (0.47) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL7666314 | 0.75 | L3MBTL1 (0.49) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12825409 | 0.74 | LMNA (0.47) | S1PR4TTRSLC6A2SLC6A3HPGD | |
| SCHEMBL196490 | 0.72 | TTR (0.62) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| SCHEMBL29687129 | 0.72 | TTR (0.62) | TTRSLC6A2SLC6A3HPGDNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |