Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657692 | 0.85 | CD274 (0.46) | CXCR4PNPKDM4ELMNAMEN1 | |
| SCHEMBL7654878 | 0.84 | CXCR4 (0.41) | CXCR4PNPKDM4ELMNAMEN1 | |
| SCHEMBL7104789 | 0.82 | PNP (0.41) | PNPKDM4EMEN1KMT2A | |
| SCHEMBL7662084 | 0.77 | CXCR4 (0.52) | CXCR4LMNAMEN1KMT2ACD274 | |
| SCHEMBL7663658 | 0.72 | CXCR4 (0.35) | CXCR4PNPCD274PDCD1ALDH1A1 | |
| SCHEMBL7106463 | 0.72 | PNP (0.36) | PNP | |
| SCHEMBL7663595 | 0.72 | TRPV3 (0.44) | CXCR4PNPKDM4ENPSR1DNM1 | |
| SCHEMBL7663573 | 0.72 | PNP (0.36) | PNPALDH1A1NPSR1ADRB2CYP1A2 | |
| SCHEMBL30707740 | 0.70 | LMNA (0.42) | CXCR4KDM4ELMNAMEN1KMT2A | |
| SCHEMBL23529999 | 0.69 | CXCR4 (0.38) | CXCR4LMNAMEN1KMT2ACD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |