Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654878 | 0.86 | CXCR4 (0.41) | CD274PDCD1CXCR4MEN1LMNA | |
| SCHEMBL7662068 | 0.85 | CXCR4 (0.43) | CD274PDCD1CXCR4MEN1LMNA | |
| SCHEMBL7103571 | 0.83 | PNP (0.42) | CD274PDCD1LMNADNM1KDM4E | |
| SCHEMBL7662084 | 0.76 | CXCR4 (0.52) | CD274PDCD1CXCR4MEN1LMNA | |
| SCHEMBL7108772 | 0.73 | PNP (0.38) | CD274PDCD1DNM1KDM4EPNP | |
| SCHEMBL7656011 | 0.73 | TRPV3 (0.43) | CD274PDCD1CXCR4DNM1KDM4E | |
| SCHEMBL18117061 | 0.73 | DNM1 (0.56) | MEN1LMNAKMT2ADNM1KDM4E | |
| SCHEMBL7659608 | 0.73 | PNP (0.38) | CD274PDCD1DNM1PNPACHE | |
| SCHEMBL10533348 | 0.72 | DNM1 (0.57) | MEN1LMNAKMT2ADNM1KDM4E | |
| SCHEMBL3079282 | 0.72 | DNM1 (0.57) | MEN1LMNAKMT2ADNM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |