Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 3/20 | 0.33 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674978 | 0.97 | ALDH1A1 (0.35) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7669032 | 0.97 | LRRK2 (0.35) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7668797 | 0.96 | ALDH1A1 (0.34) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7668342 | 0.96 | PKM (0.34) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7666632 | 0.94 | ADAM17 (0.35) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7672580 | 0.93 | PKM (0.36) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7669198 | 0.93 | HSD17B10 (0.32) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7668540 | 0.93 | ALDH1A1 (0.33) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7672620 | 0.92 | CCR5 (0.33) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7671382 | 0.91 | ALDH1A1 (0.36) | PKMALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |