Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.57 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663740 | 0.87 | ALDH1A1 (0.65) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7582747 | 0.87 | LMNA (0.65) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7666345 | 0.85 | LMNA (0.57) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL7672669 | 0.84 | LMNA (0.62) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7299158 | 0.84 | ACACB (0.60) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL7671404 | 0.84 | GPR17 (0.59) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7580808 | 0.84 | HSD17B10 (0.61) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5092484 | 0.84 | MEN1 (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7667880 | 0.84 | LMNA (0.54) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL7672302 | 0.83 | GPR27 (0.72) | GPR27ENPP1ENPP2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |