SCHEMBL7299158

SCHEMBL7299158

CC(C)(C)OC(=O)CNS(=O)(=O)c1ccc2ccccc2c1

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.60
ALDH1A1 P00352 4/20 0.58
CTSS P25774 1/20 0.57
KAT6A Q92794 4/20 0.56
LMNA P02545 1/20 0.54
GAA P10253 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
POLB P06746 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
KDM4E B2RXH2 1/20 0.52
MAPT P10636 1/20 0.52
PKM P14618 1/20 0.51
CYP19A1 P11511 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
TPSAB1 Q15661 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8428222 0.88 RAPGEF3 (0.54) ACACBALDH1A1CTSSKAT6ALMNA
SCHEMBL5729430 0.87 ACACB (0.47) ACACBALDH1A1CTSSKAT6ALMNA
SCHEMBL7663141 0.84 GPR27 (0.59) ALDH1A1KAT6ALMNAKDM4EMAPT
SCHEMBL28588397 0.83 ALDH1A1 (0.51) ALDH1A1GAASMN1; SMN2POLBNPSR1
SCHEMBL10420167 0.83 GAA (0.65) ALDH1A1CTSSKAT6AGAAPOLB
SCHEMBL14045828 0.82 ALDH1A1 (0.59) ALDH1A1CTSSKAT6APOLBNPSR1
SCHEMBL6786683 0.82 ACACB (0.64) ACACBALDH1A1CTSSKAT6ALMNA
SCHEMBL8318684 0.80 CTSS (0.65) ALDH1A1CTSSKAT6ALMNAGAA
SCHEMBL9895812 0.80 ACACB (0.61) ACACBALDH1A1KAT6ALMNAGAA
SCHEMBL7244008 0.80 MEP1B (0.59) ALDH1A1GAASMN1; SMN2POLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127340-A ESPCECIALLY THROMBIN, IN WHICH THE P1-P2 NATURAL AMIDE LINKAGE IS REPLACED BY ANOTHER BOND; INHIBITING COAGULATION OF BLOOD IN A CONTAINER; TREATMENT OR PREVENTION OF THROMBOSIS TRIGEN LIMITED (GB) 2000-10-03 US disclosed
US-5763436-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
EP-0809650-A1 SERINE PROTEASE INHIBITORS ELLERMAN PHARMACEUTICALS LIMITED (GB) 1997-12-03 EP disclosed
US-5595999-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1997-01-21 US disclosed
US-5583133-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US disclosed
WO-1996025427-A1 SERINE PROTEASE INHIBITORS ELLERMAN PHARMACEUTICALS LIMITED (GB) 1996-08-22 WO disclosed
US-5532232-A INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD HOFFMANN-LA ROCHE INC. (US) 1996-07-02 US disclosed
US-5393760-A Cardiovascular disorders, antitumor agents HOFFMANN-LA ROCHE INC. (US) 1995-02-28 US disclosed
EP-0468231-B1 Guanidins HOFFMANN LA ROCHE (CH) 1994-09-21 EP disclosed
US-5260307-A Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma HOFMANN-LA ROCHE INC. (US) 1993-11-09 US disclosed
EP-0468231-A2 Guanidins F. HOFFMANN-LA ROCHE AG (CH) 1992-01-29 EP disclosed