Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663832 | 0.84 | HRH3 (0.66) | HRH3 | |
| SCHEMBL7665528 | 0.82 | HRH3 (0.46) | HRH3ACKR3 | |
| SCHEMBL7667137 | 0.80 | HRH3 (0.48) | HRH3 | |
| SCHEMBL7658659 | 0.77 | HRH3 (0.68) | HRH3 | |
| SCHEMBL7669477 | 0.75 | HRH3 (0.49) | HRH3 | |
| SCHEMBL7666194 | 0.74 | HRH3 (0.47) | HRH3 | |
| SCHEMBL7655572 | 0.74 | PRMT6 (0.38) | HRH3MEN1KMT2APOLB | |
| SCHEMBL7666593 | 0.73 | HRH3 (0.71) | HRH3 | |
| SCHEMBL7662367 | 0.73 | HRH3 (0.38) | HRH3 | |
| SCHEMBL7667123 | 0.72 | HRH3 (0.45) | HRH3MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495569-B1 | CHEMOKINE ANTAGONISTS; TREATING DISEASE ASSOCIATED WITH INFLAMMATION AND/OR PATHOGENIC LEUKOCYTE RECRUITMENT AND/OR ACTIVATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |
| WO-2002085862-A1 | IMIDAZOLIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |