Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669477 | 0.91 | HRH3 (0.49) | HRH3PRMT6 | |
| SCHEMBL7663832 | 0.86 | HRH3 (0.66) | HRH3 | |
| SCHEMBL7667123 | 0.84 | HRH3 (0.45) | HRH3SMN1; SMN2 | |
| SCHEMBL7667137 | 0.82 | HRH3 (0.48) | HRH3CYP2D6CYP2C9HIF1AALDH1A1 | |
| SCHEMBL7658659 | 0.79 | HRH3 (0.68) | HRH3 | |
| SCHEMBL6740296 | 0.77 | HRH3 (0.44) | HRH3CYP2D6CYP2C9HIF1A | |
| SCHEMBL7665528 | 0.76 | HRH3 (0.46) | HRH3 | |
| SCHEMBL7655572 | 0.75 | PRMT6 (0.38) | HRH3PRMT6SMN1; SMN2TDP1CYP2D6 | |
| SCHEMBL7666593 | 0.75 | HRH3 (0.71) | HRH3 | |
| SCHEMBL7664837 | 0.74 | HRH3 (0.48) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495569-B1 | CHEMOKINE ANTAGONISTS; TREATING DISEASE ASSOCIATED WITH INFLAMMATION AND/OR PATHOGENIC LEUKOCYTE RECRUITMENT AND/OR ACTIVATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |
| WO-2002085862-A1 | IMIDAZOLIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |