Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663832 | 0.84 | HRH3 (0.66) | HRH3 | |
| SCHEMBL7666194 | 0.82 | HRH3 (0.47) | HRH3ALDH1A1CYP2D6CYP2C9HIF1A | |
| SCHEMBL7664837 | 0.80 | HRH3 (0.48) | HRH3 | |
| SCHEMBL7669477 | 0.80 | HRH3 (0.49) | HRH3 | |
| SCHEMBL7667123 | 0.80 | HRH3 (0.45) | HRH3 | |
| SCHEMBL7665528 | 0.79 | HRH3 (0.46) | HRH3 | |
| SCHEMBL7655572 | 0.78 | PRMT6 (0.38) | HRH3KDM4EALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL7658659 | 0.76 | HRH3 (0.68) | HRH3 | |
| SCHEMBL7662367 | 0.76 | HRH3 (0.38) | HRH3CYP2D6CYP2C9HIF1A | |
| SCHEMBL10668832 | 0.74 | PRMT6 (0.50) | HRH3KDM4EALDH1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495569-B1 | CHEMOKINE ANTAGONISTS; TREATING DISEASE ASSOCIATED WITH INFLAMMATION AND/OR PATHOGENIC LEUKOCYTE RECRUITMENT AND/OR ACTIVATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |