Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 4/20 | 0.41 |
| ▸ | RXRB | P28702 | 4/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280584 | 0.83 | LMNA (0.44) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL6688847 | 0.80 | PTGS1 (0.39) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL3475755 | 0.77 | TSHR (0.44) | TSHRCA2RXRARXRBALDH1A1 | |
| SCHEMBL29239614 | 0.77 | TSHR (0.42) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL15523219 | 0.76 | ALOX15 (0.47) | TSHRFFAR1ALDH1A1HPGDKDM4E | |
| SCHEMBL21768343 | 0.76 | TP53 (0.43) | TSHRCA2RXRARXRBALDH1A1 | |
| SCHEMBL25394857 | 0.73 | NPC1 (0.47) | GAATSHRALDH1A1HPGDNR1H4 | |
| SCHEMBL180350 | 0.73 | TSHR (0.42) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL25395879 | 0.73 | NPC1 (0.47) | GAATSHRALDH1A1HPGDNR1H4 | |
| SCHEMBL28164518 | 0.73 | FAAH (0.38) | LMNAGAATSHRABCC4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372727-B1 | ADMINISTERING IRON PORPHYRIN TO TREAT AMYOTROPHIC LATERAL SCLEROSIS; TREATING OXIDATIVE INJURY RELATED TO PEROXYNITRITE | UAB RESEARCH FOUNDATION | 2002-04-16 | — | — | US | claimed |
| US-6372727-B1 | ADMINISTERING IRON PORPHYRIN TO TREAT AMYOTROPHIC LATERAL SCLEROSIS; TREATING OXIDATIVE INJURY RELATED TO PEROXYNITRITE | UAB RESEARCH FOUNDATION | 2002-04-16 | — | — | US | disclosed |